Provocation Test Toxic Metals

A (chronic) intoxication with toxic metals like lead, mercury, cadmium, etc. poses a great threat to the functioning of our organs. For instance, lead has a detrimental effect on brain cells and the kidneys. Mercury has a bad influence on the central nervous system, the immune system and all mucous membranes, hence it is notorious for inducing allergies. Cadmium accumulates in liver, pancreas and kidneys. Several of these metals, such as arsenic and cadmium, have been classified as class I carcinogens by the World Health Organization, which means, that it has been established that these metals cause cancer in humans. We are contaminated by the air we breathe, the food we eat, the water we drink, amalgam fillings and vaccinations. In principle, all metals are toxic, but there is a considerable difference in toxicity between metals, depending on concentration. For instance, mercury is several hundred times more toxic than lead in equal amounts.

Toxic metals may cause all kind of often vague symptoms which doctors do not associate readily to be attributed by these metals. In these cases a Metal Provocation test might render a solution. In chronic situations, when the metal enters the body in relative small accumulative amounts they cannot be sufficiently found in the patient’s blood. A few hours after  the contamination metals may migrate already to several organs, i.e. liver, lymph nodes, and perhaps the brain.




The provocation test will provoke these metals out of the various organs so that they will be excreted with the urine that will be sent to the lab to determine the toxic metal concentrations. The provocation test is carried with two injections which specifically bind those toxic metals. These injections leave the body within a few hours, bound to these metals.

A blood test for toxic metals has only value in acute or massive intoxication.

In order not to get any toxic metals in the body to contaminate results of the test, it is not allowed to eat any seafood two days before the test, so no fish, shrimps, and mussels, because they are notorious for containing toxic metals, and this may influence the test.

Prior to the test no smoking starting from the evening before the test, because you do not want to measure the cadmium in your cigarettes.
Also, no supplements starting from the evening before the test, because they may contain minerals.

The day of the test one should not eat or drink anything, except water. Tea may contain manganese.
Diabetics can eat crackers but without any sandwich filling. They should write down exactly what they have eaten to be accounted for  in the result of the test.

However, you need to take you prescribes medication!

The provocation test runs as follows :

Before the first injection we ask you to empty the bladder.  A venous puncture will allow us to inject two different chelating agents (DTPA and DMPS) which will provoke the metals. This will take between 30 and 45 minutes: 10-15 minutes for the first injection, then a 10 minutes break, and then the second injection. During this second injection you will drink a first glass of water. After the second injection the venous catheter is removed. You will have to stay about two more hours from that moment. You will drink one or two glasses of water additionally, depending on whether you can hold up urine easily or not. The urine one and a half hour after the injections is will be collected. We will provide a cup to take a sample of this urine. During the test it is not allowed to eat or drink anything else.

After the test you could experience side effects like a headache, but this is uncommon. Another side effect (seldom) is itching or red discolouration at or around the site of the venous puncture. In a few cases people feel nauseated. Most of the times the side effects occur in people which are extremely burdened with toxic metals.

The urine sample will be sealed in a special tube that is made ready for transport. This parcel need to taken to a post office and mailed to Micro Trace Minerals in Hersbruck, Germany.